Search results for "From ACP Journal Club"
In Barrett esophagus, high- vs low-dose esomeprazole improved clinical outcomes; aspirin vs no aspirin did not
The safety of high-dose proton-pump inhibitor therapy is probably acceptable, but the addition of aspirin carries more risk, has less evidence on efficacy, and needs an individualized approach, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/12/28/10.htm
28 Dec 2018
In uncomplicated acute appendicitis, 61% of patients initially treated with antibiotics had not had appendectomy at 5 years
While delay of surgery was not associated with major complications, potential candidates for nonsurgical management of uncomplicated acute appendicitis should be chosen carefully, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/01/25/7.htm
25 Jan 2019
Cholecystectomy reduced major complications vs catheter drainage in high-risk patients with acute cholecystitis
A Dutch trial showed that older patients without life-threatening comorbidities may benefit from early surgical intervention, but the results would be more generalizable if the study had included patients from a broader age range, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/03/22/7.htm
22 Mar 2019
Genotypic resistance–guided and medication-guided therapies did not differ for eradicating refractory H pylori
Patients with Helicobacter pylori infection had similar cure rates with resistance-guided and medication-guided therapy, an unexpected finding, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/03/22/6.htm
22 Mar 2019
In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding
The results of this randomized trial do not support current guidelines, which recommend withholding antiplatelet drugs to reduce risk for postpolypectomy bleeding, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/07/26/9.htm
26 Jul 2019
In compensated cirrhosis with portal hypertension, beta-blockers reduced a composite of decompensation or death
The trial results cannot be generalized to all patients with cirrhosis, and future trials should look at whether similar effects could be achieved simply by limiting salt intake, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/08/23/10.htm
23 Aug 2019
Aspirin before fecal immunochemical testing did not increase sensitivity for detecting advanced colorectal neoplasms
The results of the randomized trial do not support routinely recommending aspirin before fecal immunochemical testing for colorectal cancer screening, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/08/23/9.htm
23 Aug 2019
In US veterans, PPIs were linked to increased all-cause and some cause-specific mortality compared with H2-blockers
The observational study cannot establish causation, and the only way to prove that proton-pump inhibitors (PPIs) cause the various adverse outcomes attributed to them is to compare them with placebo or no treatment in a randomized trial, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/09/27/11.htm
27 Sep 2019
Pantoprazole did not reduce risk for a composite of upper gastrointestinal events in stable arterial disease
Given the limitations of this large industry-funded trial, the only definitive conclusion one can draw is that patients on aspirin and rivaroxaban with low risk for bleeding may get a very small benefit from long-term proton-pump inhibitor therapy, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/10/25/8.htm
25 Oct 2019
In reflux-related heartburn unresponsive to PPIs, surgery increased treatment success vs active medical treatment
An ACP Journal Club commentary noted that physicians should not change their practice based on the results of the trial, which are in contrast to the literature and expert opinion, until they are confirmed by studies assessing objective primary end points.
https://gastroenterology.acponline.org/archives/2020/03/27/12.htm
27 Mar 2020