Search results for "Constipation"
Constipation associated with higher stroke risk
Constipated patients had a 50% higher risk of ischemic stroke than those without constipation, according to a recent meta-analysis.
https://gastroenterology.acponline.org/archives/2025/01/24/2.htm
24 Jan 2025
MKSAP Quiz: 6-month history of constipation
A 52-year-old man is evaluated for a 6-month history of constipation. He has bowel movements once every 5 days, low back pain after 2 days without a bowel movement, and straining during defecation. He reports no abdominal pain. After a physical exam and lab tests, what is the most appropriate management?
https://gastroenterology.acponline.org/archives/2023/11/17/4.htm
17 Nov 2023
In persons with constipation or IBS-C, kiwifruit vs. psyllium increased spontaneous bowel movements
Findings of the randomized trial bolster recommendations of diet manipulation and lifestyle modifications for chronic constipation syndromes, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/05/26/7.htm
26 May 2023
Guidance issued on pharmacologic treatment of chronic idiopathic constipation
The joint clinical practice guideline from the American Gastroenterological Association and the American College of Gastroenterology reviewed evidence on fiber, osmotic laxatives, stimulant laxatives, secretagogues, and a serotonin type 4 agonist.
https://gastroenterology.acponline.org/archives/2023/05/26/1.htm
26 May 2023
Response to linaclotide for IBS constipation can still appear after four weeks
An industry-funded analysis of four randomized trials of linaclotide for irritable bowel syndrome (IBS) with constipation found that improvement in abdominal and bowel symptoms occurred after four weeks of treatment in 1 in 6 and 1 in 10 patients, respectively.
https://gastroenterology.acponline.org/archives/2022/12/23/6.htm
23 Dec 2022
Severe COVID-19 associated with more IBS, less constipation
A prospective multicenter study found that patients hospitalized for COVID-19 had significantly higher rates of irritable bowel syndrome (IBS) and fewer problems with constipation at 12 months than controls.
https://gastroenterology.acponline.org/archives/2022/12/23/1.htm
23 Dec 2022
Recommendations for pharmacologic management of IBS with diarrhea, constipation
New guidelines suggest that there are several effective drugs available for irritable bowel syndrome (IBS), but a more detailed analysis indicates that the best treatments increase the rate of response by only 15% versus placebo, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2022/11/18/8.htm
18 Nov 2022
Systematic review compares over-the-counter treatments for chronic constipation
Polyethylene glycol and senna had good evidence for their use as first-line laxatives, while moderate evidence supported fiber supplements, fruits, stimulant laxatives, and magnesium-based products.
https://gastroenterology.acponline.org/archives/2021/06/25/3.htm
25 Jun 2021
FDA strengthens warning that schizophrenia drug can lead to life-threatening constipation
The agency is strengthening an existing warning that constipation caused by clozapine can uncommonly progress to serious bowel complications that can lead to hospitalization or death if not diagnosed and treated quickly.
https://gastroenterology.acponline.org/archives/2020/02/28/7.htm
28 Feb 2020
MKSAP quiz: Persistent constipation for 2 years
This month's quiz asks readers to determine the most appropriate treatment for persistent constipation in a 60-year-old woman taking chronic opioid analgesic therapy for reflex sympathetic dystrophy syndrome.
https://gastroenterology.acponline.org/archives/2018/12/28/4.htm
28 Dec 2018
AGA issues guideline on opioid-induced constipation
Opioid-induced constipation differs mechanistically from other forms of the disorder, and its medical management deserves dedicated attention, the American Gastroenterological Association (AGA) said.
https://gastroenterology.acponline.org/archives/2018/10/26/1.htm
26 Oct 2018
In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk
Clinical judgment will be needed to determine whether the relatively modest improvement in outcomes will be important to patients for whom the drug is considered, according to an accompanying ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2018/07/27/9.htm
27 Jul 2018
MKSAP quiz: Long-term refractory constipation
This month's quiz asks readers to determine the most appropriate management for a 36-year-old woman with a 12-year history of refractory constipation that began after a difficult childbirth.
https://gastroenterology.acponline.org/archives/2018/06/22/3.htm
22 Jun 2018
Naloxone, naldemedine appear best for opioid-induced constipation after laxatives
A meta-analysis found naloxone to have the highest efficacy and safety of pharmacological therapies for opioid-induced constipation, and previous research has shown it to be cost-effective, study authors said.
https://gastroenterology.acponline.org/archives/2018/05/25/1.htm
25 May 2018
Drug options available for opioid-induced constipation
Four FDA-approved drugs for opioid-induced constipation form the backbone of treatment, with more options in the research pipeline.
https://gastroenterology.acponline.org/archives/2018/04/27/7.htm
27 Apr 2018
Mu-opioid receptor antagonists appear safe, effective for opioid-induced constipation, review finds
Researchers looked at randomized controlled trials of peripheral mu-opioid receptor antagonists (methylnaltrexone, naloxone, naloxegol, alvimopan, axelopran, or naldemedine) and the prescription-strength laxatives lubiprostone or prucalopride.
https://gastroenterology.acponline.org/archives/2018/02/23/2.htm
23 Feb 2018
In chronic severe functional constipation, electroacupuncture increased complete spontaneous bowel movements
Patients undergoing electroacupuncture experienced a change from baseline in mean complete spontaneous bowel movements per week during the treatment period, and treatment effects were even greater after patients stopped attending the sessions.
https://gastroenterology.acponline.org/archives/2017/01/27/9.htm
27 Jan 2017
Drug for chronic idiopathic constipation approved
The oral medication is taken once per day and works in the upper GI tract to stimulate secretion of intestinal fluid, supporting regular bowel function.
https://gastroenterology.acponline.org/archives/2017/01/27/7.htm
27 Jan 2017
Improving celiac disease diagnosis
Celiac disease should be a differential diagnosis in patients with several classic clinical presentations, but atypical symptoms, including constipation, can cause doctors to overlook some patients.
https://gastroenterology.acponline.org/archives/2023/02/24/6.htm
24 Feb 2023
Case reports published on gastroenterology, hepatology topics
Reports on purple urine in a patient with chronic constipation, long-term use of metronidazole mimicking hepatic encephalopathy, and chronic lymphocytic leukemia involving the liver were published in the past month.
https://gastroenterology.acponline.org/archives/2022/09/23/9.htm
23 Sep 2022