Improving celiac disease diagnosis

Celiac disease should be a differential diagnosis in patients with several classic clinical presentations, but atypical symptoms, including constipation, can cause doctors to overlook some patients.

A cover story in the February ACP Internist focused on the diagnosis and treatment of patients with celiac disease, which remains an underdiagnosed condition. Experts explained the diagnostic workup, the difference between celiac disease and nonceliac gluten sensitivity, the role of genetic testing, and how to set patients up for success with the only treatment currently available: a lifelong gluten-free diet.