In the News
GLP-1 RAs associated with increased risk of gallstones, reflux, meta-analysis finds
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) did not significantly increase the risk of pancreatitis, cholecystitis, intestinal obstruction, or other serious gastrointestinal or biliary events.
Systematic review highlights need to test IBS patients for celiac disease
Of 7,209 patients diagnosed with irritable bowel disease (IBS), 6% were seropositive for celiac disease, according to a review of studies conducted in countries where such testing was not routine.
Screening men with HIV for anal cancer most cost-effective when initiated at age 35
In men with HIV infection who have sex with men, incremental cost-effectiveness ratios ranged from $87,731 for quadrennial cytology to $350,100 for annual cytology beginning at age 35 years, a microsimulation model found.
MKSAP Quiz: Progressive dysphagia to solids
A 64-year-old man is evaluated for progressive dysphagia to solids, a 6.8-kg (15.0-lb) weight loss over the past 3 months, and chest pressure during meals. He does not have heartburn, regurgitation, or coughing. Following a physical exam, what is the most appropriate diagnostic test to perform next?
Spotlight on steatotic liver disease types
Recent studies compared the prevalence and outcomes of metabolic dysfunction-associated steatotic liver disease (MSALD), alcohol-related liver disease (ALD), and the combination of both, known as metabolic alcohol-related liver disease (MetALD).
FIT screening for CRC before age 50 years associated with reduced mortality
Biennial screening with fecal immunochemical tests (FITs) starting at ages 40 to 49 years was associated with greater reductions in colorectal cancer (CRC) mortality and incidence than starting at age 50 years, a cohort study in Taiwan found.
Gen X, millennials showing higher rates of appendix cancer than previous generations
Incidence rates of appendiceal adenocarcinoma were four times higher among individuals born in the late 1980s than in those born in the 1940s at the same point in their lives, a cohort study found.
Fecal transplant noninferior to vancomycin for first C. diff infection, trial finds
The Clostridioides difficile cure rate was statistically noninferior and numerically higher in patients randomized to fecal microbiota transplantation instead of vancomycin for an initial C. difficile infection, a small open-label trial in Norway found.
ADA consensus report calls for MASLD, liver fibrosis screening in type 2 diabetes
A two-tier system for stratifying patients based on their risk of metabolic dysfunction-associated steatotic liver disease (MASLD) was recommended by the American Diabetes Association (ADA).
From Annals of Internal Medicine: Clinical Cases
Case reports detail syphilitic hepatitis, chronic granulomatous pancreatitis.