In the News

Noninvasive methods show promise for CRC screening

A DNA blood-based test had approximately 83% sensitivity for colorectal cancer (CRC) and 13% sensitivity for advanced precancerous lesions in one industry-funded study, while a next-generation multitarget stool DNA test showed higher sensitivity but lower specificity for CRC and advanced precancerous lesions than fecal immunochemical testing in another.

Review finds antibiotics associated with heightened risk of inflammatory bowel disease

There was a positive, nonlinear dose-response association between the number of antibiotic prescriptions patients received and their inflammatory bowel disease risk, according to a systematic review.

Tranexamic acid may help with upper GI bleeding after esophageal variceal ligation

Tranexamic acid significantly reduced upper GI bleeding after esophageal variceal ligation, but mortality rates were similar to those with placebo, a trial in India found.

MKSAP Quiz: Frequent watery, nonbloody diarrhea

A 25-year-old woman is evaluated for frequent watery, nonbloody diarrhea that began 5 years ago. She has a 2-year history of arthralgia and headaches. Diarrhea, arthralgia, and headaches resolved after the patient started a gluten-free diet 1 year ago. Symptoms occasionally return if she accidentally consumes gluten. Following a physical exam and lab tests, what is the most appropriate diagnostic test to perform next?

Spotlight on Janus kinase inhibitors

Recent studies assessed speed of response to upadacitinib in Crohn's disease, compared upadacitinib and tofacitinib for ulcerative colitis, and judged the effectiveness and safety of tofacitinib in older patients with ulcerative colitis.

In the Clinic: Acute colonic diverticulitis

A recent article provided an evidence-based, clinically relevant overview of the diagnosis and treatment of acute colonic diverticulitis.