The joint clinical practice guideline from the American Gastroenterological Association and the American College of Gastroenterology reviewed evidence on fiber, osmotic laxatives, stimulant laxatives, secretagogues, and a serotonin type 4 agonist.
Researchers sought to learn how patient characteristics vary by stages of liver scarring and how U.S. physicians manage nonalcoholic steatohepatitis (NASH).
An analysis of the prevalence of metabolic syndrome and alcohol use in the U.S. between 1999 and 2018 found that while the proportion of patients with metabolic syndrome and nonheavy alcohol use grew the most, liver disease increased the most among those who drank heavily.
An intervention that required mandatory approval from an infectious diseases physician before testing for Clostridioides difficile was associated with a greater than 50% decrease in hospital-onset C. difficile infection rates at one hospital.
Findings of the randomized trial bolster recommendations of diet manipulation and lifestyle modifications for chronic constipation syndromes, an ACP Journal Club commentary said.
In H pylori infection, vonoprazan plus high-dose amoxicillin was noninferior to B-quadruple therapy for eradication
While the dual therapy provides another promising option for Helicobacter pylori eradication, replicating the findings in more diverse patient populations would provide additional reassurance about widespread use, an ACP Journal Club commentary noted.
Upadacitinib (Rinvoq) is now approved to treat adult patients with moderately to severely active Crohn's disease who have had an inadequate response or intolerance to one or more tumor necrosis factor blockers.