Search results for "From ACP Journal Club"
In persons with constipation or IBS-C, kiwifruit vs. psyllium increased spontaneous bowel movements
Findings of the randomized trial bolster recommendations of diet manipulation and lifestyle modifications for chronic constipation syndromes, an ACP Journal Club commentary said.
26 May 2023
In H pylori infection, vonoprazan plus high-dose amoxicillin was noninferior to B-quadruple therapy for eradication
While the dual therapy provides another promising option for Helicobacter pylori eradication, replicating the findings in more diverse patient populations would provide additional reassurance about widespread use, an ACP Journal Club commentary noted.
26 May 2023
In adults receiving mechanical ventilation, selective decontamination of the digestive tract reduces hospital mortality
While findings of the meta-analysis did not show evidence of increased incidence of antimicrobial-resistant organisms, the review included data from regions that have very low levels of antimicrobial resistance, an ACP Journal Club commentary noted.
24 Mar 2023
In adults using oral anticoagulants, PPI use may be associated with lower risk for upper GI bleeding
An ACP Journal Club commentary on the meta-analysis stressed the importance of assessing patients' underlying risk for GI bleeding and using overall clinical risk to guide shared decision making in those at higher risk or with lower baseline bleeding tolerance.
18 Nov 2022
In active UC, upadacitinib induced and maintained remission
JAK inhibitors, such as upadacitinib, represent an advance in the management of patients with ulcerative colitis (UC); however, it remains unclear whether the balance of efficacy versus risk favors one drug over the others, according to an ACP Journal Club commentary.
28 Oct 2022
Recommendations for pharmacologic management of IBS with diarrhea, constipation
New guidelines suggest that there are several effective drugs available for irritable bowel syndrome (IBS), but a more detailed analysis indicates that the best treatments increase the rate of response by only 15% versus placebo, an ACP Journal Club commentary said.
18 Nov 2022
In active Crohn disease, risankizumab increased clinical remission and endoscopic response at 12 wk
While the FDA has now approved risankizumab for adults with moderate to severe Crohn disease, understanding of the drug's role in relation to other biologic therapies is limited by broad exclusion criteria in randomized controlled trials, an ACP Journal Club commentary noted.
28 Oct 2022
In older patients receiving aspirin, H pylori eradication reduced hospitalization or death due to peptic ulcer bleeding at 2.5 y
Several limitations of the trial may affect the extent to which the results will change current practice of Helicobacter pylori eradication in patients receiving aspirin, especially older patients, an ACP Journal Club commentary noted.
21 Apr 2023
In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding
The results of this randomized trial do not support current guidelines, which recommend withholding antiplatelet drugs to reduce risk for postpolypectomy bleeding, an ACP Journal Club commentary said.
26 Jul 2019
In IBS, a smartphone application for self-managing a FODMAP-lowering diet vs. otilonium bromide reduced symptoms at 8 wk
Delivery of a fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP)-lowering dietary intervention via an app may help educate patients about diet and augment the clinician-patient relationship, an ACP Journal Club commentary noted.
26 Aug 2022