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In Barrett esophagus, high- vs low-dose esomeprazole improved clinical outcomes; aspirin vs no aspirin did not

The safety of high-dose proton-pump inhibitor therapy is probably acceptable, but the addition of aspirin carries more risk, has less evidence on efficacy, and needs an individualized approach, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/12/28/10.htm
28 Dec 2018

Lowering colorectal cancer screening age from 50 to 45 years appears cost-effective

Initiating screening at age 45 years would require an additional 10 million colonoscopies, which could potentially provide greater benefit if used instead to increase screening rates in older patients, authors of the modeling study said.
https://gastroenterology.acponline.org/archives/2019/04/26/1.htm
26 Apr 2019

Screening for Lynch syndrome less effective at older ages, study finds

Lynch syndrome is rare after age 80 years, making the efficiency of universal screening very low, so stopping reflex screening in this age group may be reasonable, particularly in resource-limited settings, the study authors said.
https://gastroenterology.acponline.org/archives/2019/06/28/1.htm
28 Jun 2019

Model supports high-intensity surveillance after detection of colorectal adenomas

The target population was U.S. patients ages 50, 60, or 70 years with low-risk or high-risk adenomas removed after screening via colonoscopy or fecal immunochemical testing.
https://gastroenterology.acponline.org/archives/2019/09/27/10.htm
27 Sep 2019

In high-risk patients with acute upper GI bleeding, urgent vs. early endoscopy did not differ for 30-day mortality

While a randomized trial found no better outcomes with endoscopy within six hours of gastroenterology consult, “middle-of-the-night” endoscopy should still be considered for certain higher-risk patients who were excluded from the trial, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2020/08/28/7.htm
28 Aug 2020

Best practices for HCV care include less invasive testing for many patients, says ACP

The College's new advice on treating hepatitis C virus (HCV) identifies patients who can be safely treated in primary care with laboratory monitoring limited to the beginning and end of treatment and no invasive testing.
https://gastroenterology.acponline.org/archives/2020/10/23/6.htm
23 Oct 2020

Model that blends machine learning, traditional risk score may improve cirrhosis prediction

Using clinical variables identified from simple machine learning in a cirrhosis mortality model produced a new score that was more transparent than a commonly used version of the Model for End-Stage Liver Disease, a study found.
https://gastroenterology.acponline.org/archives/2020/11/20/3.htm
20 Nov 2020

Studies examine impact of hospital policies on C. difficile infection rates

While one study found that participation in an antibiotic stewardship program from the Agency for Healthcare Research and Quality led to reductions in hospital-onset Clostridioides difficile infection rates, a simulation study found that visitor contact precautions may not be as helpful.
https://gastroenterology.acponline.org/archives/2021/03/26/7.htm
26 Mar 2021

Spotlight on COVID-19's impact on gastroenterology

Speakers at Digestive Disease Week shared research on how the COVID-19 pandemic has affected health care utilization, telehealth, and outcomes for patients with GI cancers.
https://gastroenterology.acponline.org/archives/2021/05/28/6.htm
28 May 2021

In recurrent C difficile infection, oral FMT capsules have a pooled cure rate of 82% (low-quality evidence)

While the findings of a recent study are promising for oral fecal microbiota transplantation (FMT) capsules to treat patients with recurrent Clostridioides difficile infection, more well-designed trials are needed before routine use, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2021/06/25/8.htm
25 Jun 2021

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