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Reformulation of extended-release oxycodone may have triggered increase in hepatitis C rates

Hepatitis C virus infections increased three times faster in states with above-median rates of initial misuse of extended-release oxycodone (OxyContin) than in states with below-median rates, and the increase began immediately after a reformulation of the drug in 2010.
https://gastroenterology.acponline.org/archives/2019/02/22/1.htm
22 Feb 2019

Spotlight on direct-acting antivirals

Studies of contemporary populations with hepatitis C virus infection demonstrated that treatment with direct-acting antiviral therapies was linked to improvement in several long-term clinical outcomes.
https://gastroenterology.acponline.org/archives/2019/02/22/5.htm
22 Feb 2019

Alcohol-related liver disease more likely to be diagnosed at advanced stages, study finds

On the other hand, viral hepatitis-related disease and nonalcoholic fatty liver disease are more likely to be treated early, due in part to the development of effective drugs for the former and increased awareness of the latter.
https://gastroenterology.acponline.org/archives/2019/02/22/3.htm
22 Feb 2019

More liver transplants occurring in patients with alcohol-associated liver disease

The increase from 2002 to 2016 can partly be explained by reductions in hepatitis C-related transplants but may also indicate changing perspectives on abstinence requirements, study authors said.
https://gastroenterology.acponline.org/archives/2019/01/25/4.htm
25 Jan 2019

MKSAP Quiz: New-onset ascites

This month's quiz asks readers to determine appropriate management for a 55-year-old man with hepatitis C-related cirrhosis who is hospitalized for new-onset ascites.
https://gastroenterology.acponline.org/archives/2018/11/27/4.htm
27 Nov 2018

Transplant of HCV-infected kidneys to HCV-negative recipients yields good outcomes at 12 months

The study authors concluded that their results should encourage efforts to increase use of hepatitis C virus (HCV)-infected kidneys and called for larger confirmatory trials.
https://gastroenterology.acponline.org/archives/2018/08/24/7.htm
24 Aug 2018

HCV-infected kidney transplants appear cost-effective in recipients with HCV

Transplanting a hepatitis C virus (HCV)-infected kidney and then administering HCV treatment was more effective and cost less than transplanting an HCV-uninfected kidney after HCV treatment in HCV-infected patients, mainly because the waiting list for uninfected kidneys is longer.
https://gastroenterology.acponline.org/archives/2018/07/27/6.htm
27 Jul 2018

Spotlight on mortality trends in liver disease

One study looked at 10-year U.S. mortality trends related to chronic liver diseases, while another assessed mortality from cirrhosis and liver cancer in the U.S. from 1999 to 2016.
https://gastroenterology.acponline.org/archives/2018/07/27/5.htm
27 Jul 2018

Spotlight on hepatocellular cancer

One recent study assessed occurrence of hepatocellular carcinoma in patients with hepatitis C-associated cirrhosis, while another looked at the effect of hepatobiliary cancer surveillance on outcomes in patients with primary sclerosing cholangitis.
https://gastroenterology.acponline.org/archives/2018/04/27/6.htm
27 Apr 2018

Prophylactic HCV treatment with direct-acting antivirals appears safe in noninfected kidney recipients

Researchers studied 10 HCV-negative recipients of 10 HCV-positive donor kidneys in an open-label, nonrandomized trial.
https://gastroenterology.acponline.org/archives/2018/03/23/3.htm
23 Mar 2018

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