Search results for "From ACP Journal Club"
In US veterans, PPIs were linked to increased all-cause and some cause-specific mortality compared with H2-blockers
The observational study cannot establish causation, and the only way to prove that proton-pump inhibitors (PPIs) cause the various adverse outcomes attributed to them is to compare them with placebo or no treatment in a randomized trial, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/09/27/11.htm
27 Sep 2019
In mild acute diverticulitis, outpatient therapy without antibiotics was noninferior to antibiotics
The DINAMO-study is the first outpatient trial to show that withholding antibiotics may not have inferior outcomes, although the results may be partly explained by use of NSAIDs and/or acetaminophen in both groups, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2022/02/25/9.htm
25 Feb 2022
Aspirin before fecal immunochemical testing did not increase sensitivity for detecting advanced colorectal neoplasms
The results of the randomized trial do not support routinely recommending aspirin before fecal immunochemical testing for colorectal cancer screening, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/08/23/9.htm
23 Aug 2019
In adults using oral anticoagulants, PPI use may be associated with lower risk for upper GI bleeding
An ACP Journal Club commentary on the meta-analysis stressed the importance of assessing patients' underlying risk for GI bleeding and using overall clinical risk to guide shared decision making in those at higher risk or with lower baseline bleeding tolerance.
https://gastroenterology.acponline.org/archives/2022/11/18/9.htm
18 Nov 2022
In high-risk patients with acute upper GI bleeding, urgent vs. early endoscopy did not differ for 30-day mortality
While a randomized trial found no better outcomes with endoscopy within six hours of gastroenterology consult, “middle-of-the-night” endoscopy should still be considered for certain higher-risk patients who were excluded from the trial, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2020/08/28/7.htm
28 Aug 2020
In moderately to severely active UC, etrasimod increased remission at 12 and 52 wk but increased adverse events
Given their overall safety and convenience, etrasimod and other oral sphingosine-1-phosphate receptor modulators can be considered as first-line therapy in clinically appropriate patients with ulcerative colitis (UC) who do not respond to 5-aminosalicylic acid medications, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/07/28/7.htm
28 Jul 2023
Recommendations for pharmacologic management of IBS with diarrhea, constipation
New guidelines suggest that there are several effective drugs available for irritable bowel syndrome (IBS), but a more detailed analysis indicates that the best treatments increase the rate of response by only 15% versus placebo, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2022/11/18/8.htm
18 Nov 2022
In uncomplicated, left-sided acute diverticulitis, observation did not differ from antibiotics for recovery
At 6-month follow-up, no differences were found in time to recovery, readmission, development of complications, or mortality in patients assigned to observation or those assigned to antibiotics.
https://gastroenterology.acponline.org/archives/2017/02/24/7.htm
24 Feb 2017
In recurrent C difficile infection, oral FMT capsules have a pooled cure rate of 82% (low-quality evidence)
While the findings of a recent study are promising for oral fecal microbiota transplantation (FMT) capsules to treat patients with recurrent Clostridioides difficile infection, more well-designed trials are needed before routine use, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2021/06/25/8.htm
25 Jun 2021
In adults receiving mechanical ventilation, selective decontamination of the digestive tract reduces hospital mortality
While findings of the meta-analysis did not show evidence of increased incidence of antimicrobial-resistant organisms, the review included data from regions that have very low levels of antimicrobial resistance, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2023/03/24/11.htm
24 Mar 2023