Search results for "Highlights"
Shorter treatment possible for HCV, phase 2 study finds
Four weeks of daily glecaprevir and pibrentasvir resulted in sustained virologic response at 12 weeks in 84% of patients with early hepatitis C virus (HCV) infection, a study found.
https://gastroenterology.acponline.org/archives/2025/08/22/3.htm
22 Aug 2025
Cancer, decompensation more likely in men with cirrhosis than women
Men with cirrhosis had more than double the risk of hepatocellular carcinoma, a 63% higher risk of liver transplant, and a 16% higher risk of decompensated cirrhosis than women with the disease, and the differences were greatest in those with alcohol-related disease, a study found.
https://gastroenterology.acponline.org/archives/2025/08/22/2.htm
22 Aug 2025
FMT appears safe, effective for recurrent C. diff in immunocompromised patients
Patients with mild to moderate immunocompromise and recurrent Clostridioides difficile infection had similar outcomes to immunocompetent patients after fecal microbiota transplantation (FMT), according to a systematic review and meta-analysis.
https://gastroenterology.acponline.org/archives/2025/08/22/1.htm
22 Aug 2025
Regular CBD use linked with liver enzyme elevations, FDA trial finds
More than 5% of study participants randomized to cannabidiol (CBD) twice daily for 28 days had an alanine aminotransferase or aspartate aminotransferase level of at least three times normal, suggesting that moderate CBD doses may carry hepatic risks.
https://gastroenterology.acponline.org/archives/2025/07/25/3.htm
25 Jul 2025
Several drug classes reviewed, found unlikely to trigger microscopic colitis
Microscopic colitis rates were not elevated in patients taking NSAIDs, proton-pump inhibitors, statins, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers.
https://gastroenterology.acponline.org/archives/2025/07/25/2.htm
25 Jul 2025
Empiric treatments for Helicobacter pylori compared
Concomitant and bismuth quadruple therapies had the highest eradication rates for initial treatment, while bismuth quadruple therapy was most successful as a salvage regimen, a retrospective cohort study in the U.S. found.
https://gastroenterology.acponline.org/archives/2025/07/25/1.htm
25 Jul 2025
Systematic review highlights need to test IBS patients for celiac disease
Of 7,209 patients diagnosed with irritable bowel disease (IBS), 6% were seropositive for celiac disease, according to a review of studies conducted in countries where such testing was not routine.
https://gastroenterology.acponline.org/archives/2025/06/27/2.htm
27 Jun 2025
Screening men with HIV for anal cancer most cost-effective when initiated at age 35
In men with HIV infection who have sex with men, incremental cost-effectiveness ratios ranged from $87,731 for quadrennial cytology to $350,100 for annual cytology beginning at age 35 years, a microsimulation model found.
https://gastroenterology.acponline.org/archives/2025/06/27/3.htm
27 Jun 2025
GLP-1 RAs associated with increased risk of gallstones, reflux, meta-analysis finds
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) did not significantly increase the risk of pancreatitis, cholecystitis, intestinal obstruction, or other serious gastrointestinal or biliary events.
https://gastroenterology.acponline.org/archives/2025/06/27/1.htm
27 Jun 2025
Incidentally detected gallbladder polyps often get unneeded follow-up
Over more than two years of follow-up, gallbladder polyps increased in size in 26.0% of patients, and although cholecystectomy and follow-up imaging were commonly performed, no malignant polyps were detected, a retrospective study found.
https://gastroenterology.acponline.org/archives/2025/05/23/3.htm
23 May 2025
Nuts, seeds did not trigger diverticulitis in women, study finds
Although intake of peanuts, nuts, and seeds or fresh fruits with edible seeds was not associated with incident diverticulitis, women who reported healthier diets had lower risk of the condition, a cohort study found.
https://gastroenterology.acponline.org/archives/2025/05/23/2.htm
23 May 2025
Review suggests infliximab superior to cyclosporine for acute severe ulcerative colitis
Infliximab was superior to cyclosporine for reducing the risk of colectomy in patients with acute severe ulcerative colitis, although infection risk was higher with infliximab, a meta-analysis of 44 studies found.
https://gastroenterology.acponline.org/archives/2025/05/23/1.htm
23 May 2025
Study supports bariatric surgery in patients with obesity and cirrhosis
An economic evaluation of Veterans Health Administration data found that bariatric surgery was cost-effective among patients with cirrhosis at a willingness-to-pay threshold of $100,000 per quality-adjusted life-year.
https://gastroenterology.acponline.org/archives/2025/04/25/3.htm
25 Apr 2025
Patient navigation improves colonoscopy completion at 1 year, study finds
Rates of follow-up colonoscopy in a U.S. study were higher in patients assigned to receive telephone-based navigation after an abnormal stool test versus usual care.
https://gastroenterology.acponline.org/archives/2025/04/25/2.htm
25 Apr 2025
Universal HDV screening in patients with HBV appears cost-effective
Compared with status quo screening rates, universal hepatitis D virus (HDV) testing of adults with chronic hepatitis B virus (HBV) infection could avert 100 HDV-related deaths, an additional 30 cases of cirrhosis, and 50 cases of hepatocellular carcinoma per 100,000 people screened, according to a modeling study.
https://gastroenterology.acponline.org/archives/2025/04/25/1.htm
25 Apr 2025
Mailed FIT, patient navigation increased CRC screening in rural Medicaid enrollees
A program that mailed fecal immunochemical tests (FITs) to Medicaid enrollees and implemented patient navigation to colonoscopies after an abnormal result increased colorectal cancer screening participation at six months by 7.3 percentage points compared with usual care, according to a multicenter trial.
https://gastroenterology.acponline.org/archives/2025/03/28/3.htm
28 Mar 2025
AKI in cirrhosis can still show response to albumin after 24 hours, study finds
After 48 hours of albumin treatment, between 30% and 54% of patients with cirrhosis and acute kidney injury (AKI) had responded (depending on the definition of response). At 24 hours, only 25% to 38% had shown a response, a prospective study found.
https://gastroenterology.acponline.org/archives/2025/03/28/2.htm
28 Mar 2025
First-of-kind guideline outlines surveillance of premalignant gastric conditions
Goals of the new guideline from the American College of Gastroenterology include reducing gastric cancer incidence, improving the detection of early-stage disease, and significantly increasing five-year survival rates.
https://gastroenterology.acponline.org/archives/2025/03/28/1.htm
28 Mar 2025
Machine learning model predicted mortality among malnourished inpatients with IBD
Integrating such models into clinical practice could improve identification of inflammatory bowel disease (IBD) patients at risk for malnutrition and potentially reduce their mortality by prompting earlier intervention, according to the authors of a new study.
https://gastroenterology.acponline.org/archives/2025/02/28/3.htm
28 Feb 2025
GLP-1 receptor agonists negatively impact colonoscopy bowel preparation, review finds
Patients taking glucagon-like peptide-1 (GLP-1) receptor agonists were more than twice as likely to experience inadequate bowel preparation for colonoscopy than those not taking the medications, a meta-analysis found.
https://gastroenterology.acponline.org/archives/2025/02/28/2.htm
28 Feb 2025