Search results for "Highlights"
Spotlight on treatment response in Crohn's disease
Recent studies evaluated early versus late response to biologic therapy, treatment response and infection risk, and endoscopic outcomes.
https://gastroenterology.acponline.org/archives/2024/01/26/5.htm
26 Jan 2024
In symptomatic adults undergoing high-resolution manometry, long-term opioid use was linked to esophageal dysmotility
The results of a recent meta-analysis highlight the need for clinicians to widen their perspective on the risks of opioids to include both upper and lower GI motility disorders, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/12/22/8.htm
22 Dec 2023
For ulcerative colitis, ustekinumab safe, effective through 4 years, industry study finds
Most patients who had symptomatic remission of their ulcerative colitis on the drug maintained it without corticosteroids, an extension of a randomized trial found.
https://gastroenterology.acponline.org/archives/2023/12/22/3.htm
22 Dec 2023
Thalidomide reduced bleeding in patients with small-intestinal angiodysplasia
A total of 68.6% of patients who were randomized to 100 mg of thalidomide daily (taken in four doses a day) had a reduction of at least 50% in bleeding episodes in the year after treatment compared to 16% of those on placebo.
https://gastroenterology.acponline.org/archives/2023/12/22/2.htm
22 Dec 2023
No-biopsy approach can diagnose celiac disease in select adults
IgA anti-tissue transglutaminase levels of at least 10 times the upper limit of normal have a sensitivity of 51% and specificity of 100% for predicting celiac disease in adults referred to secondary care, a meta-analysis found.
https://gastroenterology.acponline.org/archives/2024/01/26/1.htm
26 Jan 2024
Low-dose amitriptyline appears effective as second-line treatment for IBS
Patients with irritable bowel syndrome (IBS) who were randomized to titrated doses of a tricyclic antidepressant had significant improvements in their IBS symptom scores at six months compared to those receiving a placebo, a trial in primary care found.
https://gastroenterology.acponline.org/archives/2023/10/27/2.htm
27 Oct 2023
Fenofibrate may augment treatment for primary biliary cholangitis
Adding fenofibrate to ursodeoxycholic acid significantly increased the likelihood of biochemical response and normalization of alkaline phosphatase levels, a small trial in China found.
https://gastroenterology.acponline.org/archives/2023/11/17/3.htm
17 Nov 2023
Concurrent cholinesterase inhibitors, NSAIDs linked to peptic ulcer risk
Risk of peptic ulcers increased ninefold when patients ages 65 years and older took cholinesterase inhibitors and NSAIDs concurrently, a Swedish study found, leading the authors to suggest that the combination be considered potentially inappropriate for older patients.
https://gastroenterology.acponline.org/archives/2023/11/17/2.htm
17 Nov 2023
Guideline newly recommends biomarkers to monitor Crohn's disease
The American Gastroenterological Association offered advice on using blood and stool tests to monitor inflammation and reduce the frequency of invasive endoscopy.
https://gastroenterology.acponline.org/archives/2023/12/22/1.htm
22 Dec 2023
GLP-1 receptor agonists may affect colonoscopy bowel prep
A retrospective cohort study found that patients taking glucagon-like peptide-1 (GLP-1) receptor agonists for diabetes or obesity had lower-quality bowel prep for colonoscopy and were more likely to be called back for a repeat test.
https://gastroenterology.acponline.org/archives/2023/10/27/3.htm
27 Oct 2023