In the News

Empiric treatments for Helicobacter pylori compared

Concomitant and bismuth quadruple therapies had the highest eradication rates for initial treatment, while bismuth quadruple therapy was most successful as a salvage regimen, a retrospective cohort study in the U.S. found.

Several drug classes reviewed, found unlikely to trigger microscopic colitis

Microscopic colitis rates were not elevated in patients taking NSAIDs, proton-pump inhibitors, statins, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers.

Regular CBD use linked with liver enzyme elevations, FDA trial finds

More than 5% of study participants randomized to cannabidiol (CBD) twice daily for 28 days had an alanine aminotransferase or aspartate aminotransferase level of at least three times normal, suggesting that moderate CBD doses may carry hepatic risks.

MKSAP Quiz: Duodenal ulcers and bleeding

A 52-year-old man is hospitalized for 1 day of melena. Upper endoscopy revealed multiple duodenal ulcers, but the examination was limited by clots obscuring the mucosa. Following a physical exam and lab studies, what is the most appropriate management?

Spotlight on FIT outreach

One study found that patients were more likely to complete fecal immunochemical testing (FIT) with video versus pictorial instructions, while another offered a model for increasing follow-up of abnormal results.

GLP-1s associated with increased risk of GERD

Patients with type 2 diabetes who started a glucagon-like peptide-1 (GLP-1) receptor agonist had a 27% higher risk of gastroesophageal reflux disease (GERD) than those who took a sodium-glucose cotransporter-2 inhibitor, a retrospective study found.

In adults aged 50 to 69 y, invitation to screening with FIT was noninferior to invitation for colonoscopy for colorectal cancer mortality at 10 y

A recent Spanish study finding that more patients responded to invitations to fecal immunochemical testing (FIT) than colonoscopy was methodologically robust, but higher acceptance of colonoscopy in the U.S. might affect extrapolation of the findings, an ACP Journal Club commentary said.

Case report describes rare vascular tumor

A 40-year-old man presented with abdominal distention and significant weight loss.

Numerous infusion pumps recalled

In addition to announcing several recalls of infusion pumps, the FDA warned about the risk of heat injuries with the antinausea scopolamine transdermal system.