Search results for "From ACP Journal Club"
In US veterans, PPIs were linked to increased all-cause and some cause-specific mortality compared with H2-blockers
The observational study cannot establish causation, and the only way to prove that proton-pump inhibitors (PPIs) cause the various adverse outcomes attributed to them is to compare them with placebo or no treatment in a randomized trial, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/09/27/11.htm
27 Sep 2019
In compensated cirrhosis with portal hypertension, beta-blockers reduced a composite of decompensation or death
The trial results cannot be generalized to all patients with cirrhosis, and future trials should look at whether similar effects could be achieved simply by limiting salt intake, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/08/23/10.htm
23 Aug 2019
In primary biliary cholangitis, adding bezafibrate to ursodeoxycholic acid increased complete biochemical response
Bezafibrate is currently unavailable in the U.S., but fenofibrate can be offered off-label in these patients with close monitoring of adverse effects, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/10/26/8.htm
26 Oct 2018
In Barrett esophagus, high- vs low-dose esomeprazole improved clinical outcomes; aspirin vs no aspirin did not
The safety of high-dose proton-pump inhibitor therapy is probably acceptable, but the addition of aspirin carries more risk, has less evidence on efficacy, and needs an individualized approach, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/12/28/10.htm
28 Dec 2018
In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk
Clinical judgment will be needed to determine whether the relatively modest improvement in outcomes will be important to patients for whom the drug is considered, according to an accompanying ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2018/07/27/9.htm
27 Jul 2018
Colonoscopy outreach increased CRC screening more than FIT outreach; both were better than usual care
Those choosing screening tests may need to start considering the feasibility of achieving all related downstream actions as well as sensitivity, false-positive rates, safety, and cost, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/01/26/7.htm
26 Jan 2018
Glasgow Blatchford score predicted intervention or death better than 4 other prediction models in upper GI bleeding
Commentary authors writing in ACP Journal Club said the findings add to a growing body of literature that supports the use of the Glasgow Blatchford score for selecting low-risk patients who can safely be discharged from the ED (with a minimal false-negative rate).
https://gastroenterology.acponline.org/archives/2017/04/28/6.htm
28 Apr 2017