Search results for "From ACP Journal Club"
In patients receiving invasive ventilation, PPIs reduce upper GI bleeding but did not affect mortality at 90 d
An ACP Journal Club commentary said the results of the REVISE trial support the routine use of first-line proton-pump inhibitors (PPIs) for stress ulcer prophylaxis in high-risk, critically ill, ventilated patients but noted that the definition of “high risk” is uncertain.
https://gastroenterology.acponline.org/archives/2024/10/25/9.htm
25 Oct 2024
In symptomatic adults undergoing high-resolution manometry, long-term opioid use was linked to esophageal dysmotility
The results of a recent meta-analysis highlight the need for clinicians to widen their perspective on the risks of opioids to include both upper and lower GI motility disorders, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/12/22/8.htm
22 Dec 2023
A next-generation mt-sDNA test had 94% sensitivity for colorectal cancer and 91% specificity for advanced neoplasia
An ACP Journal Club commentary questioned whether multitarget stool DNA (mt-sDNA) is better than fecal immunochemical testing (FIT) or outperformed FIT because of a lower threshold for colonoscopy referral, recommending that the tests be compared at the same referral rate.
https://gastroenterology.acponline.org/archives/2024/09/27/8.htm
27 Sep 2024
In moderately to severely active UC, etrasimod increased remission at 12 and 52 wk but increased adverse events
Given their overall safety and convenience, etrasimod and other oral sphingosine-1-phosphate receptor modulators can be considered as first-line therapy in clinically appropriate patients with ulcerative colitis (UC) who do not respond to 5-aminosalicylic acid medications, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/07/28/7.htm
28 Jul 2023
In NASH with liver fibrosis, resmetirom improved NASH resolution and reduced fibrosis at 1 y
This was an interim analysis of an industry trial, and final results are needed to determine whether patients with nonalcoholic (or metabolic dysfunction-associated) steatohepatitis (NASH) show clinically meaningful benefits, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2024/06/28/11.htm
28 Jun 2024
In H pylori infection, vonoprazan plus high-dose amoxicillin was noninferior to B-quadruple therapy for eradication
While the dual therapy provides another promising option for Helicobacter pylori eradication, replicating the findings in more diverse patient populations would provide additional reassurance about widespread use, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2023/05/26/8.htm
26 May 2023
In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding
The results of this randomized trial do not support current guidelines, which recommend withholding antiplatelet drugs to reduce risk for postpolypectomy bleeding, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/07/26/9.htm
26 Jul 2019
In drug-refractory IBS, group CBT with interoceptive exposure improved symptoms and quality of life at 13 wk
Given the results of this small, randomized trial, a head-to-head comparison of multidisciplinary care versus group cognitive behavioral therapy (CBT) delivered over the internet for patients with irritable bowel syndrome (IBS) is now warranted, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2022/08/26/10.htm
26 Aug 2022
Review: In chronic hepatitis C virus infection, oral direct-acting antivirals have high sustained virologic response
A commentary in ACP Journal Club noted that while screening and treating all patients with chronic hepatitis C virus (HCV) would be cost-effective and probably cost-saving, some payers are still resistant.
https://gastroenterology.acponline.org/archives/2017/07/28/11.htm
28 Jul 2017
Vonoprazan-containing therapy has an H pylori eradication rate >90% and increases eradication vs. standard triple therapy
Results of a systematic review and network meta-analysis support a shift toward a susceptibility-based approach to Helicobacter pylori infection based on principles of antimicrobial stewardship, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2021/10/22/7.htm
22 Oct 2021