Current Issue


Screening for Lynch syndrome less effective at older ages, study finds

Lynch syndrome is rare after age 80 years, making the efficiency of universal screening very low, so stopping reflex screening in this age group may be reasonable, particularly in resource-limited settings, the study authors said.

Sodium polystyrene sulfonate associated with GI events requiring hospitalization in elderly

An accompanying editorial said that based on the risk of gastrointestinal (GI) events found in this retrospective study, sodium polystyrene sulfonate should not be used to reduce serum potassium levels.

Anti-TNF therapy did not reduce IBD hospitalizations or intestinal resections in Ontario

Infliximab may have been used inappropriately in Crohn's disease and underused in ulcerative colitis, according to the authors of an analysis of hospitalizations, intestinal resections, and drug costs related to inflammatory bowel disease (IBD).

MKSAP quiz: Management of Lynch syndrome

This month's quiz asks readers to determine the next step in management for a 30-year-old woman with Lynch syndrome, based on her family history and the identification of a genetic mutation.

Spotlight on PPI safety

Recent studies came to differing conclusions in their assessments of the safety of proton-pump inhibitors (PPIs), with outcomes including mortality, hepatic encephalopathy, and infections.

Patient dies after fecal microbiota transplantation

One immunocompromised patient died and another was infected after receiving fecal microbiota for transplantation that contained multidrug-resistant bacteria, the FDA reported.