Current Issue


Naloxone, naldemedine appear best for opioid-induced constipation after laxatives

A meta-analysis found naloxone to have the highest efficacy and safety of pharmacological therapies for opioid-induced constipation, and previous research has shown it to be cost-effective, study authors said.

Home-based cognitive behavioral therapy improved IBS symptoms

Patients with irritable bowel syndrome (IBS) who received four sessions of primarily home-based cognitive behavioral therapy had similar symptom improvement to those who went to 10 standard therapy sessions.

Misoprostol may help treat obscure GI bleeding in patients taking aspirin, NSAIDs

Complete healing of small-bowel ulcers and erosions, as assessed by video-capsule endoscopy, was significantly more common among patients receiving misoprostol than those randomized to placebo, a small British study found.

MKSAP quiz: History of heartburn

This month's quiz asks readers to evaluate a patient with heartburn that awakens him at night and is not completely relieved by over-the-counter antacids.

Spotlight on IBD and Parkinson's disease

Recent research has found that patients with inflammatory bowel disease (IBD) may have increased risk of Parkinson's disease and that this risk may be modified by anti-tumor necrosis factor therapy.

First drug approved to treat thrombocytopenia in adults with chronic liver disease who are having a medical procedure

Patients who received the drug for five days had increased platelet counts compared to those taking placebo.

Endoscopic spray device approved to be marketed to treat GI bleeding

The device delivers a mineral blend to sites of upper or lower GI bleeding and is applied during an endoscopic procedure.

Topic-specific resources available through ACP Online Learning Center

The learning center provides access to a curated collection of more than 400 online learning activities and includes a section focused specifically on gastroenterology and hepatology.

In the Clinic: Acute diverticulitis

A recent In the Clinic article offered a clinically relevant overview of the epidemiology, diagnosis, and treatment of acute diverticulitis.