Search results for "Constipation"
MKSAP quiz: Long-term refractory constipation
This month's quiz asks readers to determine the most appropriate management for a 36-year-old woman with a 12-year history of refractory constipation that began after a difficult childbirth.
https://gastroenterology.acponline.org/archives/2018/06/22/3.htm
22 Jun 2018
Mu-opioid receptor antagonists appear safe, effective for opioid-induced constipation, review finds
Researchers looked at randomized controlled trials of peripheral mu-opioid receptor antagonists (methylnaltrexone, naloxone, naloxegol, alvimopan, axelopran, or naldemedine) and the prescription-strength laxatives lubiprostone or prucalopride.
https://gastroenterology.acponline.org/archives/2018/02/23/2.htm
23 Feb 2018
AGA issues guideline on opioid-induced constipation
Opioid-induced constipation differs mechanistically from other forms of the disorder, and its medical management deserves dedicated attention, the American Gastroenterological Association (AGA) said.
https://gastroenterology.acponline.org/archives/2018/10/26/1.htm
26 Oct 2018
FDA strengthens warning that schizophrenia drug can lead to life-threatening constipation
The agency is strengthening an existing warning that constipation caused by clozapine can uncommonly progress to serious bowel complications that can lead to hospitalization or death if not diagnosed and treated quickly.
https://gastroenterology.acponline.org/archives/2020/02/28/7.htm
28 Feb 2020
Drug options available for opioid-induced constipation
Four FDA-approved drugs for opioid-induced constipation form the backbone of treatment, with more options in the research pipeline.
https://gastroenterology.acponline.org/archives/2018/04/27/7.htm
27 Apr 2018
In primary care, second-line IBS therapy with amitriptyline vs. placebo reduced symptoms at 6 mo
An ACP Journal Club commentary said the high-quality randomized trial provides pragmatic guidance on amitriptyline dosing in patients with irritable bowel syndrome (IBS), as well as additional support for the drug as an option in primary care after first-line therapies fail.
https://gastroenterology.acponline.org/archives/2024/02/23/7.htm
23 Feb 2024
Naloxone, naldemedine appear best for opioid-induced constipation after laxatives
A meta-analysis found naloxone to have the highest efficacy and safety of pharmacological therapies for opioid-induced constipation, and previous research has shown it to be cost-effective, study authors said.
https://gastroenterology.acponline.org/archives/2018/05/25/1.htm
25 May 2018
Drug for chronic idiopathic constipation approved
The oral medication is taken once per day and works in the upper GI tract to stimulate secretion of intestinal fluid, supporting regular bowel function.
https://gastroenterology.acponline.org/archives/2017/01/27/7.htm
27 Jan 2017
In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk
Clinical judgment will be needed to determine whether the relatively modest improvement in outcomes will be important to patients for whom the drug is considered, according to an accompanying ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2018/07/27/9.htm
27 Jul 2018
In chronic severe functional constipation, electroacupuncture increased complete spontaneous bowel movements
Patients undergoing electroacupuncture experienced a change from baseline in mean complete spontaneous bowel movements per week during the treatment period, and treatment effects were even greater after patients stopped attending the sessions.
https://gastroenterology.acponline.org/archives/2017/01/27/9.htm
27 Jan 2017