Search results for "Constipation"


 
Results 11 - 20 of about 51 for "Constipation".
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In symptomatic adults undergoing high-resolution manometry, long-term opioid use was linked to esophageal dysmotility

The results of a recent meta-analysis highlight the need for clinicians to widen their perspective on the risks of opioids to include both upper and lower GI motility disorders, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2023/12/22/8.htm
22 Dec 2023

FDA strengthens warning that schizophrenia drug can lead to life-threatening constipation

The agency is strengthening an existing warning that constipation caused by clozapine can uncommonly progress to serious bowel complications that can lead to hospitalization or death if not diagnosed and treated quickly.
https://gastroenterology.acponline.org/archives/2020/02/28/7.htm
28 Feb 2020

In primary care, second-line IBS therapy with amitriptyline vs. placebo reduced symptoms at 6 mo

An ACP Journal Club commentary said the high-quality randomized trial provides pragmatic guidance on amitriptyline dosing in patients with irritable bowel syndrome (IBS), as well as additional support for the drug as an option in primary care after first-line therapies fail.
https://gastroenterology.acponline.org/archives/2024/02/23/7.htm
23 Feb 2024

Drug for chronic idiopathic constipation approved

The oral medication is taken once per day and works in the upper GI tract to stimulate secretion of intestinal fluid, supporting regular bowel function.
https://gastroenterology.acponline.org/archives/2017/01/27/7.htm
27 Jan 2017

AGA issues guideline on opioid-induced constipation

Opioid-induced constipation differs mechanistically from other forms of the disorder, and its medical management deserves dedicated attention, the American Gastroenterological Association (AGA) said.
https://gastroenterology.acponline.org/archives/2018/10/26/1.htm
26 Oct 2018

Naloxone, naldemedine appear best for opioid-induced constipation after laxatives

A meta-analysis found naloxone to have the highest efficacy and safety of pharmacological therapies for opioid-induced constipation, and previous research has shown it to be cost-effective, study authors said.
https://gastroenterology.acponline.org/archives/2018/05/25/1.htm
25 May 2018

In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk

Clinical judgment will be needed to determine whether the relatively modest improvement in outcomes will be important to patients for whom the drug is considered, according to an accompanying ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2018/07/27/9.htm
27 Jul 2018

Mu-opioid receptor antagonists appear safe, effective for opioid-induced constipation, review finds

Researchers looked at randomized controlled trials of peripheral mu-opioid receptor antagonists (methylnaltrexone, naloxone, naloxegol, alvimopan, axelopran, or naldemedine) and the prescription-strength laxatives lubiprostone or prucalopride.
https://gastroenterology.acponline.org/archives/2018/02/23/2.htm
23 Feb 2018

Drug options available for opioid-induced constipation

Four FDA-approved drugs for opioid-induced constipation form the backbone of treatment, with more options in the research pipeline.
https://gastroenterology.acponline.org/archives/2018/04/27/7.htm
27 Apr 2018

Spotlight on abdominal bloating

Bloating is common throughout the world, is strongly associated with abdominal pain, and may improve with adequate doses of rifaximin, recent studies found.
https://gastroenterology.acponline.org/archives/2023/06/23/5.htm
23 Jun 2023

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