Search results for "From ACP Journal Club"
USPSTF recommends screening adults 18 to 79 years for hepatitis C virus infection with moderate certainty
An essential requirement of expanded screening is the availability of effective treatment, but randomized controlled trials to date have not shown clinical benefit of direct-acting antiviral therapy beyond sustained virologic response, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2020/07/24/7.htm
24 Jul 2020
H. pylori treatment reduced risk for gastric cancer in patients with a family history of gastric cancer
While results of the trial support a test-and-treat screening approach for Helicobacter pylori in patients with a first-degree relative with gastric cancer, more research is needed before considering universal screening in this population, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2020/06/26/7.htm
26 Jun 2020
In irritable bowel syndrome, fecal microbiota transplantation improved symptoms at 3 months
While fecal microbiota transplantation was effective in patients with moderate to severe irritable bowel syndrome in a randomized trial, long-term risks of the therapy remain uncertain, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2020/05/22/10.htm
22 May 2020
In reflux-related heartburn unresponsive to PPIs, surgery increased treatment success vs active medical treatment
An ACP Journal Club commentary noted that physicians should not change their practice based on the results of the trial, which are in contrast to the literature and expert opinion, until they are confirmed by studies assessing objective primary end points.
https://gastroenterology.acponline.org/archives/2020/03/27/12.htm
27 Mar 2020
Any of 4 screening options suggested for screen-naive adults 59 to 70 y with ≥ 3% 15-y risk for colorectal cancer
To balance shared decision making and population health in colorectal cancer screening, as called for in a recent guideline, a viable strategy could include universal, opt-out fecal immunochemical testing starting at age 50 years, a commentary in ACP Journal Club noted.
https://gastroenterology.acponline.org/archives/2020/03/27/11.htm
27 Mar 2020
Pantoprazole did not reduce risk for a composite of upper gastrointestinal events in stable arterial disease
Given the limitations of this large industry-funded trial, the only definitive conclusion one can draw is that patients on aspirin and rivaroxaban with low risk for bleeding may get a very small benefit from long-term proton-pump inhibitor therapy, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/10/25/8.htm
25 Oct 2019
In US veterans, PPIs were linked to increased all-cause and some cause-specific mortality compared with H2-blockers
The observational study cannot establish causation, and the only way to prove that proton-pump inhibitors (PPIs) cause the various adverse outcomes attributed to them is to compare them with placebo or no treatment in a randomized trial, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/09/27/11.htm
27 Sep 2019
In compensated cirrhosis with portal hypertension, beta-blockers reduced a composite of decompensation or death
The trial results cannot be generalized to all patients with cirrhosis, and future trials should look at whether similar effects could be achieved simply by limiting salt intake, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/08/23/10.htm
23 Aug 2019
Aspirin before fecal immunochemical testing did not increase sensitivity for detecting advanced colorectal neoplasms
The results of the randomized trial do not support routinely recommending aspirin before fecal immunochemical testing for colorectal cancer screening, according to an ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2019/08/23/9.htm
23 Aug 2019
In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding
The results of this randomized trial do not support current guidelines, which recommend withholding antiplatelet drugs to reduce risk for postpolypectomy bleeding, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/07/26/9.htm
26 Jul 2019