Search results for "From ACP Journal Club"
In CVD, continuing vs interrupting clopidogrel before colonoscopy did not differ for delayed postpolypectomy bleeding
The results of this randomized trial do not support current guidelines, which recommend withholding antiplatelet drugs to reduce risk for postpolypectomy bleeding, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2019/07/26/9.htm
26 Jul 2019
After surgery for stage II or III colorectal cancer, more vs less frequent follow-up did not differ for 5-year mortality
The findings help clarify the ideal process for surveillance of clinical recurrence of colorectal cancer, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/10/26/7.htm
26 Oct 2018
In IBS with constipation, plecanatide reduced abdominal pain and increased bowel movements at 12 wk
Clinical judgment will be needed to determine whether the relatively modest improvement in outcomes will be important to patients for whom the drug is considered, according to an accompanying ACP Journal Club commentary.
https://gastroenterology.acponline.org/archives/2018/07/27/9.htm
27 Jul 2018
In H pylori infection, vonoprazan plus high-dose amoxicillin was noninferior to B-quadruple therapy for eradication
While the dual therapy provides another promising option for Helicobacter pylori eradication, replicating the findings in more diverse patient populations would provide additional reassurance about widespread use, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2023/05/26/8.htm
26 May 2023
In decompensated cirrhosis, targeted albumin infusions did not improve an in-hospital composite outcome at 15 days
The results of this randomized trial should not discourage clinicians from using albumin for recognized indications, but they do not support targeting an arbitrary serum albumin level, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2021/08/27/7.htm
27 Aug 2021
In Barrett esophagus, high- vs low-dose esomeprazole improved clinical outcomes; aspirin vs no aspirin did not
The safety of high-dose proton-pump inhibitor therapy is probably acceptable, but the addition of aspirin carries more risk, has less evidence on efficacy, and needs an individualized approach, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2018/12/28/10.htm
28 Dec 2018
Daily aspirin for primary CVD prevention increased risk for major GI bleeding in healthy older adults
While aspirin is not recommended for primary prevention of cardiovascular disease (CVD) in most adults ages 70 years and older, more research is needed to assess its role in select high-risk populations of older adults, an ACP Journal Club commentary said.
https://gastroenterology.acponline.org/archives/2021/01/22/6.htm
22 Jan 2021
Invitation to a single FS screening vs. usual care reduced colorectal cancer mortality and incidence at >15 y
The SCORE trial demonstrated the long-term protective effect from flexible sigmoidoscopy (FS) screening for colorectal cancer at ages 55 to 64 years, supporting the safety of using it as a single intervention, an ACP Journal Club commentary noted.
https://gastroenterology.acponline.org/archives/2022/03/25/7.htm
25 Mar 2022
In reflux-related heartburn unresponsive to PPIs, surgery increased treatment success vs active medical treatment
An ACP Journal Club commentary noted that physicians should not change their practice based on the results of the trial, which are in contrast to the literature and expert opinion, until they are confirmed by studies assessing objective primary end points.
https://gastroenterology.acponline.org/archives/2020/03/27/12.htm
27 Mar 2020
H. pylori eradication therapy may reduce gastric cancer risk; rifabutin-based therapy effective in industry-sponsored trial
A meta-analysis suggested that, in addition to preventing progression, early Helicobacter pylori eradication therapy reduces gastric cancer risk, and a novel rifabutin-based therapy may offer physicians another option for initiating eradication treatment, an ACP Journal Club commentary on both studies said.
https://gastroenterology.acponline.org/archives/2020/09/25/9.htm
25 Sep 2020